A question that is often raised is that what are the benefits of using a 3D cell culture compared to a traditional 2D cell culture. Brinter scientists Antti Arjonen (PhD) and Sanna Turunen (D.Sc.Tech) wrote an article in the Finnish journal Solubiologi (The Cell Biologist) 2/2020 comparing the pros and cons of both methods. The original article exists in Finnish language only, but we summarized the key points to a simple table comparing 2D and 3D cell culture methods.